Enzymatic synthesis of epothilone A glycosides
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چکیده
منابع مشابه
Enzymatic synthesis of glycosides: from natural O- and N-glycosides to rare C- and S-glycosides
Carbohydrate related enzymes, like glycosyltransferases and glycoside hydrolases, are nowadays more easily accessible and are thought to represent powerful and greener alternatives to conventional chemical glycosylation procedures. The knowledge of their corresponding mechanisms has already allowed the development of efficient biocatalysed syntheses of complex O-glycosides. These enzymes can al...
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The therapeutic application of vitamin E is seri ously limited by its very low solubility in aqueous phases, and tocopherols cannot be used when in stant adm inistration of a strong antiradical and antioxidant agent is needed. To increase solubility in w ater and facilitate perm eability through cellu lar m em branes tocopherol can be attached to a carbohydrate moiety [1]. The synthesis of s...
متن کاملStudies towards the synthesis of epothilone A via organoboranes.
Studies towards the synthesis of epothilone A via organoboranes have been described. A modified procedure for the large-scale preparation of B-gamma,gamma-dimethylallyldiisopinocampheylborane from prenyl alcohol has been developed. This reagent, upon reaction with various aldehydes, provides the corresponding alpha,alpha-dimethylhomoallylic alcohols in high enantioselectivities. The application...
متن کاملStereoselective Synthesis of C - Glycosides with a
K . Karaghiosoff, G. Jochem. A. Schmidpeter, unpublished. S. Lochschmidt, A. Schmidpeter. Phosphorus Sulr;r 1986.29, 73-109. a) G. A. Gray, J. Am. Chem. Sac. 1973, 95. 7736-7742; b) G. Fronza, P. Bravo. C. Ticozzi, J. Orgunornet. Chem. 1978, f57, 299-310; c )M. Schlosser, T. Jenny, B. Schaub, Heteroat. Chem. 1990. 1, 151-156. If the phosphonio group at the C atom and the substituent at the P at...
متن کاملSynthesis and biological evaluation of epothilone A dimeric compounds.
The preparation and biological evaluation of a novel series of dimeric epothilone A derivatives (1-6) are described. Two types of diacyl spacers were introduced to establish the various dimeric epothilone A constructs. The effect of these compounds on tubulin polymerization and their cytotoxicity against four different cancer cell lines are reported. Several of the newly synthesized compounds i...
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ژورنال
عنوان ژورنال: AMB Express
سال: 2014
ISSN: 2191-0855
DOI: 10.1186/s13568-014-0031-1